GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2275426 | 1 | rs12139630 | chr1:46350935 | CCDC163P | chr1:45960581-45965646:- | -0.37 | -7 | 1.16E-11 | Body mass index |
| BLCA | cis | rs6684514 | 1 | rs12141236 | chr1:156302575 | BGLAP | chr1:156182784-156213112:+ | 0.22 | 3.84 | 0.000145 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BLCA | cis | rs2275426 | 1 | rs12144263 | chr1:46352446 | CCDC163P | chr1:45960581-45965646:- | -0.37 | -7 | 1.16E-11 | Body mass index |
| BLCA | cis | rs2404602 | 1 | rs12148786 | chr15:76800362 | SCAPER | chr15:76640529-77197744:- | -0.21 | -4.67 | 4.17E-6 | Blood metabolite levels |
| BLCA | cis | rs1577917 | 1 | rs12154056 | chr6:86634094 | SNHG5 | chr6:86386726-86388451:- | -0.51 | -9.01 | 9.54E-18 | Response to antipsychotic treatment |
| BLCA | cis | rs7655841 | 1 | rs12171333 | chr4:129879711 | C4orf33 | chr4:130014829-130033842:+ | 0.31 | 4.68 | 4.04E-6 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs2120019 | 1 | rs12185102 | chr15:75352201 | SCAMP5 | chr15:75287901-75313836:+ | 0.29 | 4.83 | 1.97E-6 | Blood trace element (Zn levels) |
| BLCA | cis | rs1577917 | 1 | rs12190598 | chr6:86686074 | SNHG5 | chr6:86386726-86388451:- | -0.49 | -7.97 | 1.88E-14 | Response to antipsychotic treatment |
| BLCA | cis | rs1577917 | 1 | rs12190604 | chr6:86716215 | SNHG5 | chr6:86386726-86388451:- | -0.51 | -8.98 | 1.2E-17 | Response to antipsychotic treatment |
| BLCA | cis | rs9491140 | 1 | rs12192208 | chr6:124693764 | NKAIN2 | chr6:124125069-125146784:+ | 0.28 | 4.76 | 2.8E-6 | Neuroticism |
| BLCA | cis | rs1577917 | 1 | rs12192992 | chr6:86609915 | SNHG5 | chr6:86386726-86388451:- | -0.53 | -9.42 | 4.49E-19 | Response to antipsychotic treatment |
| BLCA | cis | rs1577917 | 1 | rs12196037 | chr6:86694631 | SNHG5 | chr6:86386726-86388451:- | -0.53 | -9.35 | 7.19E-19 | Response to antipsychotic treatment |
| BLCA | cis | rs1577917 | 1 | rs12196411 | chr6:86779762 | SNHG5 | chr6:86386726-86388451:- | -0.54 | -9.34 | 7.81E-19 | Response to antipsychotic treatment |
| BLCA | cis | rs9473555 | 1 | rs12196937 | chr6:49382808 | CENPQ | chr6:49431096-49460820:+ | -0.28 | -5.66 | 2.91E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs12196937 | chr6:49382808 | MUT | chr6:49398994-49431031:- | 0.28 | 5.53 | 5.94E-8 | Folate pathway vitamin levels |